Zwei interessante Studien bezüglich Quetiapin

[Maya]

Hallo liebe Gruppe

Vielen Dank für Euren vielen Links und Informationen in der wirklich gut bestückten Datenbank und hier im Forum!
In den Psychologendatenbanken habe ich mal einige Abstracts zu neueren Studien über Baclofen überflogen – die Ergebnisse sind recht unterschiedlich. Bei den Studien deren Ergebnisse Baclofen als nur so wirksam wie Placebos zeigen ist die Stichprobengröße durchgängig zu klein (was so auch dort zugegeben wird).

Diese Studien fand ich z.B. interessant:

The dose–effect relationship of baclofen in alcohol dependence: A 1‐year cohort study
Human Psychopharmacology: Clinical and Experimental, Vol 32(4), Jul, 2017
Baptiste Pignon, Julien Labreuche, Marine Auffret, Sophie Gautier, Sylvie Deheul, Nicolas Simioni, Olivier Cottencin, Régis Bordet, Alain Duhame, Benjamin Rolland
Abstract:
Objective: Our aim is to study the relationship between dose of baclofen and effectiveness in alcohol dependence. Methods: Two hundred two patients with alcohol dependence, who received baclofen treatment for drinking reduction, were followed up for 1 year. For each patient‐month of treatment, the maximum daily dose of baclofen (DDB) and average weekly alcohol consumption (AWAC) were calculated. We defined a favorable drinking outcome as an AWAC under 200 g/ w for at least 2 consecutive months. We divided the DDB of each patient‐month into 3 categories (low dose: < 90 mg/d, medium dose: 90–150 mg/d, and high dose: > 150 mg/d) and investigated the relationship between reaching a favorable outcome and the concurrent DDB category in a time‐varying Cox regression analysis. Hazard ratios (HRs) were adjusted based on age, sex, and initial AWAC. Results: One hundred forty subjects were followed during at least 1 month. Of these patients, 58 (41%) had a favorable drinking outcome. In comparison to low dose, medium dose was associated with a decreased rate of favorable drinking outcome (HR = 0.42; 95% CI [0.20, 0.88]), whereas no difference was found with high dose (HR = 1.31; 95% CI [0.65, 2.64]). Conclusion: The relationship between dose of baclofen and favorable drinking outcome was U‐shaped, that is, was increased at low and high doses compared to medium doses.

R(+)-baclofen, but not S(−)-baclofen, alters alcohol self-administration in alcohol-preferring rats
Frontiers in Psychiatry, Vol 7, Apr 18, 2016
Lorrai, Irene; Maccioni, Paola; Gessa, Gian Luigi; Colombo, Giancarlo
Abstract:
Racemic baclofen [(±)-baclofen] has repeatedly been reported to suppress several alcohol-motivated behaviors, including alcohol drinking and alcohol s elf-administration, in rats and mice. Recent data suggested that baclofen may have bidirectional, stereospecific effects, with the more active enantiomer, R(+)-baclofen, suppressing alcohol intake and the less active enantiomer, S(−)-baclofen, stimulating alcohol intake in mice. The present study was designed to investigate whether this enantioselectivity of baclofen effects may also extend to the reinforcing properties of alcohol in rats. To this end, selectively bred Sardinian alcohol-preferring (sP) rats were initially trained to lever respond on a fixed ratio 4 (FR4) schedule of reinforcement for alcohol (15%, v/v) in daily 30-min sessions. Once responding had stabilized, rats were tested with vehicle, (±)-baclofen (3 mg/kg), R(+)-baclofen (0.75, 1.5, and 3 mg/kg), and S(−)-baclofen (6, 12, and 24 mg/kg) under the FR4 schedule of reinforcement. Treatment with 3 mg/kg (±)-baclofen reduced the number of lever responses for alcohol and estimated amount of self-administered alcohol by approximately 60% in comparison to vehicle treatment. R(+)-baclofen was approximately twice as active as (±)-baclofen: treatment with 1.5 mg/ kg R(+)-baclofen decreased both variables to an extent similar to that of the decreasing effect of 3 mg/kg (±)-baclofen. Conversely, treatment with all doses of S(−)-baclofen failed to affect alcohol self administration. These results (a) confirm that non-sedative doses of (±)-baclofen effectively suppressed the reinforcing properties of alcohol in sP rats and (b) apparently do not extend to operant alcohol self-administration in sP rats the capability of S(−)-baclofen to stimulate alcohol drinking in mice.


Spannend.

Wie ist das, kann ich die Studien einfach hier im Threat hochladen, oder schickt man die besser als PN an Dich, DonQuixote?

Euch noch eine gute Nacht,
liebe Grüße,
Maya